Nuclear Oncoprotein Prothymosin Is a Partner of Keap1: Implications for Expression of Oxidative Stress-Protecting Genes
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Nuclear Oncoprotein Prothymosin Is a Partner of Keap1: Implications for Expression of Oxidative Stress-Protecting Genes Ruben N. Karapetian, Alexandra G. Evstafieva, Irina S. Abaeva, Nina V. Chichkova, Grigoriy S. Filonov, Yuri P. Rubtsov, Elena A. Sukhacheva, Sergey V. Melnikov, Ulrich Schneider, Erich E. Wanker, and Andrey B. Vartapetian* Belozersky Institute of Physico-Chemical Biology, Moscow State University, and Shemiakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, and Max Planck Institute for Molecular Genetics and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
منابع مشابه
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.
Animal cells counteract oxidative stress and electrophilic attack through coordinated expression of a set of detoxifying and antioxidant enzyme genes mediated by transcription factor Nrf2. In unstressed cells, Nrf2 appears to be sequestered in the cytoplasm via association with an inhibitor protein, Keap1. Here, by using the yeast two-hybrid screen, human Keap1 has been identified as a partner ...
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Intrinsically disordered proteins (IDPs) are abundant in cells and have central roles in protein-protein interaction networks. Interactions between the IDP Prothymosin alpha (ProTα) and the Neh2 domain of Nuclear factor erythroid 2-related factor 2 (Nrf2), with a common binding partner, Kelch-like ECH-associated protein 1(Keap1), are essential for regulating cellular response to oxidative stres...
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The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity is opposed by the BTB/POZ domain protein Keap1. Keap1 is proposed to regulate Nrf2 activity strictly through its capacity to inhibit Nrf2 nuclear import. Recent work suggests that inhibition of Nrf2 may also depend upon ubiquitin-mediated proteolysis. To address the contributi...
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In response to oxidative stress, nuclear factor (erythroid-derived 2)-like2 (Nrf2) induces expression of cytoprotective genes. The Nrf2 pathway is controlled by microRNAs and Kelch-like ECH-associated protein1 (Keap1). Nrf2 is stabilized when Keap1 is degraded through the autophagy pathway in a p62-dependent manner. The inhibition of autophagy causes protein accumulation, and Keap1 is inactivat...
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تاریخ انتشار 2005